Alcoholic liver disease and alcoholism: two diseases, one problem
https://doi.org/10.21518/2079-701X-2013-10-38-41
Abstract
The article highlights alcoholic liver disease manifested in steatosis/steatohepatitis/fibrosis, which further transforms into cirrhosis of the liver. The pathogenetic mechanisms of alcohol-induced lesions of the liver leading to steatosis/steatohepatitis are described. Section on the treatment of alcoholic steatohepatitis provides a review of current data on the use of drugs supported by strong evidence and recommendations. The authors also share results of their own research on quality of life and impact of somatic complaints in patients with different types of fatty liver disease.
About the Authors
A. A. Samsonov
MSUMD named after A.I. Evdokimov, Russian Ministry of Health
Russian Federation
Russian Federation
E. Y. Plotnikova
Subepartment of primary care training, course director for clinical gastroenterology Kemerovo State Medical Academy, Russian Ministry of Health, Kemerovo
Russian Federation
Russian Federation
I. N. Nikushkina
MSUMD named after A.I. Evdokimov, Russian Ministry of Health
Russian Federation
Russian Federation
E. A. Talitskaya
Gastroenterology unit at City Clinical Hospital No. 1, Novokuznetsk
Russian Federation
Russian Federation
M. V. Krasnova
Gastroenterology unit at Kuzbass Regional Centre for Hepatology, Clinical Hospital No. 3 named after M.A. Podgorbunskiy, Kemerovo
Russian Federation
Russian Federation
O. A. Krasnov
Subdepartment of hospital surgery of Kemerovo State Medical Academy, Russian Ministry of Health, chief doctor at Clinical Hospital No. 3 named after M.A. Podgorbunskiy, Kemerovo
Russian Federation
Russian Federation
References
1. Patrick C.H. Alcohol, Culture, and Society. Durham, NC: Duke University Press. 1952. Р. 12–13.
2. Savolainen V.T., Liesto K. M nnikk A. et al. Alcohol consumption and alcoholic liver disease: Evidence of a threshold level of effects of ethanol // Alcohol. Clin. Exp. Res. 1993. №17(5). Р. 1112–1117.
3. Lelbach W.K. Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse // Ann. N.Y. Acad. Sci. 1975. №252. Р. 85–105.
4. Grant B.F., Dufour M.C., Harford T.C. Epidemiology of alcoholic liver disease // Semin. Liver. Dis. 1988. №8(1). Р. 12–25.
5. Crabb D.W. Pathogenesis of alcoholic liver disease: newer mechanisms of injury // Keio. J. Med. 1999. №48. Р. 184–188.
6. Lieber C.S., Jones D.P., Decarli L.M. Effects of prolonged ethanol intake: production of fatty liver despite adequate diets // J. Clin. Invest. 1965. №44. Р. 1009–1021.
7. Mendenhall C.L. Anabolic steroid therapy as an adjunct to diet in alcoholic hepatic steatosis // Am. J. Dig. Dis. 1968. №13. Р. 783–791.
8. Leevy C.M. Fatty liver: a study of 270 patients with biopsy proven fatty liver and review of the literature // Medicine (Baltimore). 1962. №41. Р. 249–276.
9. Sorensen T.I., Orholm M., Bentsen K.D., Hoybye G., Eghoje K., Christoffersen P. Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis // Lancet. 1984. №2. Р. 241–244.
10. NIAAA. Eighth Report to the U.S. Congress on Alcohol and Health, 1994.
11. Maddrey W.C. Alcoholic hepatitis: Clinicopathologic features and therapy // Semin. Liv. Dis. 1998. №8(1). Р. 91–102.
12. O’Shea R.S., Dasarathy S., McCullough A.J. Alcoholic Liver Disease // Hepatology. 2010. №51(1). Р. 307–328.
13. Новик А.А., Ионова Т.И. Руководство по исследованию качества жизни в медицине // СПб.: Издательский дом «Нева», 2002.
14. Голдынкина Е.А. Гиссенский опросник давления соматических жалоб / Е.А. Голдынкина, Г.Л. Исурина. СПб.: Психоневрологический институт им. В.М. Бехтерева. 1992.
15. Pharmacotherapy for alcohol dependence. Summary, Evidence Report / Technology Assessment. 1999. №3. Jan. Agency for Health Care Policy and Research. Rockville, MD.
16. Srisurapanont M., Jarusuraisin N. Opioid antagonists for alcohol dependence // Cochrane Database Syst. Rev. 2005. CD001867.
17. Palmer A.J., Neeser K., Weiss C., Brandt A., Comte S., Fox M. The longterm cost-effectiveness of improving alcohol abstinence with adjuvant acamprosate // Alcohol. 2000. №35. Р. 478–492.
18. Mason B.J. Acamprosate in the treatment of alcohol dependence // Expert Opin. Pharmacother 2005. №6. Р. 2103–2115.
19. Anton RF, O’Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, et al. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA 2006;295:2003-2017.
20. Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, et al. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. Lancet 2007;370:1915-1922.
21. Mezey E. Interaction between alcohol and nutrition in the pathogenesis of alcoholic liver disease. Semin Liver Dis 1991;11:340-348.
22. Mendenhall CL, Tosch T, Weesner RE, et al: VA cooperative study on alcoholic hepatitis II: Prognostic significance of protein-calorie malnutrition. Am J Clin Nutr 1986;43:213-218.
23. O'Shea RS, Dasarathy S, McCullough AJ: Alcoholic Liver Disease. Hepatology 2010;51(1):307-328.
24. Mendenhall CL, Tosch T, Weesner RE, et al: VA cooperative study on alcoholic hepatitis II: Prognostic significance of protein-calorie malnutrition. Am J Clin Nutr 1986;43:213-218.
25. Schenker S, Halff GA: Nutritional therapy in alcoholic liver disease. Semin Liver Dis 1993;13(2):196-209.
26. Carithers RL, Herlong HF, Diehl AM, et al: Methylprednisolone therapy in patients with severe alcoholic hepatitis. Ann Intern Med 1989;110:685-690.
27. Ramond MJ, Poynard T, Rueff B, et al: A randomized trial of prednisolone in patients with severe alcoholic hepatitis. N Engl J Med 1992;326:507-512.
28. Depew W, Boyer T, Omata M, et al: Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy. Gastroenterol 1980;78(3):524-529.
29. Theodossi A, Eddleston ALWF, Williams R: Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis. Gut 1982; 23(1):75-79.
30. O'Shea RS, Dasarathy S, McCullough AJ: Alcoholic Liver Disease. Hepatology 2010;51(1):307-328.
31. Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology 2000;119: 1637-1648.
32. Menon KV, Stadheim L, Kamath PS, Wiesner RH, Gores GJ, Peine CJ, et al. A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis. Am J Gastroenterol 2004;99:255-260.
33. Burra P, Lucey MR. Liver transplantation in alcoholic patients. Transpl Int 2005;18:491-498.
34. O’Grady JG. Liver transplantation alcohol related liver disease: (deliberately) stirring a hornet’s nest! Gut 2006;55:1529-1531.
35. Aertgeerts B. Buntinx F, Kester A: The value of the CAGE in screening for alcohol abuse and alcohol dependence in general clinical populations: a diagnostic meta-analysis. J Clin Epidemiol 2004;57:30-39.
Review
For citations:
Samsonov AA, Plotnikova EY, Nikushkina IN, Talitskaya EA, Krasnova MV, Krasnov OA. Alcoholic liver disease and alcoholism: two diseases, one problem. Meditsinskiy sovet = Medical Council. 2013;(10):38-41. (In Russ.) https://doi.org/10.21518/2079-701X-2013-10-38-41
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