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Pathogenetic justification and experience in using anti-adhesion gel in patients with intrauterine synechia after surgical hysteroscopy

https://doi.org/10.21518/2079-701X-2018-13-160-164

Abstract

The article highlights the concept of the mechanisms of formation of intrauterine synechia, which represents an important medical and social problem. Its relevance is due to the violation of the reproductive function of women and in severe forms of the disease has irreversible consequences. Surgical intervention remains the leading method of treatment for such patients. However, in complex clinical situations, its application is associated with the formation of a vicious circle, aggravating the severity of the pathological process. Therefore, today, high hopes are placed on the application of methods for the prevention of the disease and its relapse. Our data on this issue allow us to optimize the use of non-surgical high-tech methods for the prevention of Asherman’s syndrome. The use of anti-adhesive resorbable gel Antiadhesin is described and its pathogenetic application is justified.

About the Authors

E. E. Arutyunova
Kulakov National Medical Research Centre for Obstetrics, Gynaecology and Perinatology, Federal State Budgetary Institution В.И. of the Ministry of Health of Russia
Russian Federation
Moscow


N. A. Buralkina
Kulakov National Medical Research Centre for Obstetrics, Gynaecology and Perinatology, Federal State Budgetary Institution В.И. of the Ministry of Health of Russia
Russian Federation
Moscow


V. D. Chuprynin
Kulakov National Medical Research Centre for Obstetrics, Gynaecology and Perinatology, Federal State Budgetary Institution В.И. of the Ministry of Health of Russia
Russian Federation
Moscow


V. E. Zhorova
Kulakov National Medical Research Centre for Obstetrics, Gynaecology and Perinatology, Federal State Budgetary Institution В.И. of the Ministry of Health of Russia
Russian Federation
Moscow


References

1. AAGL Practice Report : Practice Guidelines for Management of Intrauterine Synechiae. J Minim Invasive Gynecol. 2010 Jan-Feb;17(1):1-7.

2. Infertile couple. Modern approaches to diagnosis and treatment: a guide/ under the editorship of Sukhikh GТ, Nazarenko ТА. Moscow: GEOTAR-Media, 2010. 784 p.

3. Senturk L. M., Erel C. T. 2008. Thin endometrium in assisted reproductive technology. Curr. Opin. Obstet. Gynecol. 20 : 221—228.

4. Sidelnikova VМ. Habitual miscarriage: modern view on the problem. Obstetrics and Gynecology. 2007. 5. P. 24-27.

5. Ceccaldi PF, Nguyen T, Mandelbrot L. Unusual synechia at hysterosalpingography: intrauterine fallopian tube after surgical abortion. Fertil Steril. 2011; 95(6): 2078-9.

6. Takai I.U., Kwayabura A.S., Ugwa E.A. A 10-year Review of the Clinical Presentation and Treatment Outcome of Asherman’s Syndrome at a Center with Limited Resources. Annals Of Medical And Health Sciences Research. 2015. 5(6). 442–446.

7. Yu D, Wong YM, Cheong Y, Xia E, Li TC: Asherman syndrome-one century later. Fertil Steril. 2008. 89. 759–779.

8. Klyucharov IV, Khasanov AA. Diagnosis and treatment of intrauterine synechia by microhysteroscopy. Obstetrics and gynecology, PM. Actual problems of medicine. 2012. 1. 15-23.

9. Kulakov VI, Adamyan LV. Endoscopy and alternative approaches to the surgical treatment of female diseases. M., 2001. 556-557.

10. March C. M. 2011. Management of Ashermans syndrome. Reprodþ Biomedþ Online. 23: 63-76.

11. Fernandez H., Benifla J.L., Fritel X. [et al.] / Postcurettage and aspiration synechiae: is there value in an anti-adhesion agent? // J Gynecol Obstet Biol Reprod (Paris). – 2012. 41, 2. 8-12. 50.

12. Robinson JK, Colimon LM, Isaacson KB. Postoperative adhesiolysis therapy for intrauterine adhesions (Asherman’s syndrome). Fertil Steril 2008; 90(2): 409–14.

13. Tao Z, Duan H: Expression of adhesion-related cytokines in the uterine fluid after transcervical resection of adhesion. Zhonghua Fu Chan Ke Za Zhi 2012, 47: 734–737.

14. Ibrahim MI, Raafat TA, Ellaithy MI, Aly RT: Risk of postpartum uterine synechiae following uterine compression suturing during postpartum haemorrhage. Aust N Z J Obstet Gynaecol 2013, 53:37–45.

15. Santamaria X., Cabanilla S., Cervello I., Arbona C., Raga F., Ferro J., Palmero J., Remohi J., Pellicer A., Simon C. 2016. Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman’s syndrome and endometrial atrophy: a pilot cohort study. Hum. Reprod. 31: 1087—1096.

16. Altered transcriptional regulation of cytokines, growth factors, and apoptotic proteins in the endometrium of infertile women with chronic endo metritis. /C. Di Pietro, E. Cicinelli, M.R. Guglielmino[et al.]. Am J Reprod Immunol. 2013. 69, 5. 509-17.

17. Panayiotides I, Weyers S, Bosteels J, Van Herendae B. Intrauterine adhesion (IUA): Has there been progress in understanding and treatment over last 20 years? Gynecol Surg. 2009. 6. 197–211.


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For citations:


Arutyunova EE, Buralkina NA, Chuprynin VD, Zhorova VE. Pathogenetic justification and experience in using anti-adhesion gel in patients with intrauterine synechia after surgical hysteroscopy. Meditsinskiy sovet = Medical Council. 2018;(13):160-164. (In Russ.) https://doi.org/10.21518/2079-701X-2018-13-160-164

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ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)