Adjuvant therapy in premenopausal women with hormone-dependent breast cancer
https://doi.org/10.21518/2079-701X-2018-19-73-75
Abstract
In recent years, several studies have indicated that aromatase inhibitors (AIS) combined with a gonadotropin-releasing hormone agonist (GnRH agonist) are safe and effective in premenopausal patients with hormone receptor positive (HR+) breast cancer (BCA). The ABCSG-12 trial has shown a comparable DFS for 3-eyar adjuvant therapy with anastrazol-goserelin and tamoxifengoserelin. However a combined analysis of the data from SOFT and TEXT trials demonstrated that compared with tamoxifen plus ovarian suppression, adjuvant endocrine therapy with exemestane plus GnRH agonist (Triptorelin) in premenopausal patients with a significant improved DFS and an extended interval without distant recurrence. The differing results emerging from ABCSG-12 and the TEXT and SOFT trials misht be related to higher statistical power in the combined analysis.
About the Authors
V. F. Semiglazov
Petrov National Medical Cancer Research Centre, the Ministry of Russia, St.Petersburg
Russian Federation
Russian Federation
V. Yu. Lifanova
Petrov National Medical Cancer Research Centre, the Ministry of Russia, St.Petersburg;
Modern Medical Technology Clinic, St.Petersburg
Russian Federation
Russian Federation
V. S. Appolonova
Petrov National Medical Cancer Research Centre, the Ministry of Russia, St.Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Semiglazov VF, Lifanova VY, Appolonova VS. Adjuvant therapy in premenopausal women with hormone-dependent breast cancer. Meditsinskiy sovet = Medical Council. 2018;(19):73-75. (In Russ.) https://doi.org/10.21518/2079-701X-2018-19-73-75
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