Chronic constipation (definition, epidemiology, diagnosis): current drug therapy
https://doi.org/10.21518/2079-701X-2015-13-100-105
Abstract
The most interest among laxatives used in the treatment of functional constipation is earned by Exportale (lactitol monohydrate) which belongs to osmotic laxatives. The osmotic effect is produced by its metabolites which are formed in the colon as a result of obligate enzymatic cleavage creating short-chain fatty acids, carbon dioxide and water which liquify and increase stool volume, as well as increase osmotic pressure. A study of the effectiveness of the drug was conducted in 90 patients with functional constipation aged from 60 to 84 years. The overall effectiveness of the drug for relief of constipation was 90%. The effect was accompanied by restoration of colonic motility, reduction or a tendency to restore the colonic microflora metabolites, and in patients with encephalopathy - a decrease in its severity.
About the Author
O. N. Minushkin
Teaching and Research Medical Center of the Russian Federation Presidential Administration, Moscow
Russian Federation
Russian Federation
References
1. Garrigues V et al. Prevalence of constipation agreement among several criteria and evaluation of the diagnostic accuracy of gualifying symptoms and self-reported definition in population in Spain. Am J Epidemiol, 2004, 159: 520-526.
2. Zembo A, Camilleri M. Chronic constipation. N Engl J Med, 2003, 349: 1360-1368.
3. Pare P et al. An epidemiological survey of constipation in Canada definitions rates demographics and predictors of heaith care see king. Am J gastroenterol, 2001, 96: 3130-3137.
4. Wald A et al. The Bl Omnibus study an international survey of communiry prevaleuce of constipation and laxative use in adults, Gastroenterology, 2006, 130: 508.
5. Минушкин О.Н, Елизаветина Г.А., Ардатская М.Д. Современные представления о функциональных запорах. Подходы к лечению. Фарматека, 2010, 5: 94-99.
6. Елизаветина Г.А., Минушкин О.Н. Запоры и некоторые принципы их лечения. Клиническая фармакология и терапия, 1997, 6: 51-53.
7. Румянцев В.Г, Косачева Т.А., Коров Е.А. Дифференцированное лечение запоров, Фарматека, 2004, 13: 1-6.
8. Колхир В.К. Экспортал» - иновационный слабительный препарат, РМЖ, 2009, 11(2).
9. Воскобойникова И.В., Колхир В.К., Минушкин О.Н. Лактитол (экспортал) - эффективное и безопасное слабительное, Эффективная фармакотерапия, 2009, 2,4: 14-16.
Review
For citations:
Minushkin ON. Chronic constipation (definition, epidemiology, diagnosis): current drug therapy. Meditsinskiy sovet = Medical Council. 2015;(13):100-105. (In Russ.) https://doi.org/10.21518/2079-701X-2015-13-100-105
Views:
578
Email this article 