Effect of long-term therapy with AT1angiotensin II receptor blockers in combination with aldosterone receptor inhibitor on ischemic myocardial remodelling and chronic heart failure
https://doi.org/10.21518/2079-701X-2014-12-81-85
Abstract
The article presents the results of a 6-month long-term therapy with angiotensin II receptor blocker Valsacor and aldosterone receptor blocker Spironolactone in patients with chronic heart failure (CHF) against a background of ischemic and/or post-infarction left ventricular remodelling. The results show that the renin-angiotensin-aldosterone system (RAAS) blockade in the combination therapy slows down the pathological remodelling of the left ventricle (LV) and thus prevents progression of CHF in a majority of patients with myocardial infarction (MI).
About the Authors
AT Teplyakov
Tomsk Research Institute of Cardiology
Russian Federation
Russian Federation
EV Grakova
Tomsk Research Institute of Cardiology
Russian Federation
Russian Federation
AV Andrianova
Tomsk Research Institute of Cardiology
Russian Federation
Russian Federation
Е. EY Pushnikova
Tomsk Research Institute of Cardiology
Russian Federation
Russian Federation
Н. NV Protopopova
Tomsk Research Institute of Cardiology
Russian Federation
Russian Federation
Р. RS Karpov
Tomsk Research Institute of Cardiology
Russian Federation
Russian Federation
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Review
For citations:
Teplyakov A, Grakova E, Andrianova A, Pushnikova E, Protopopova N, Karpov R. Effect of long-term therapy with AT1angiotensin II receptor blockers in combination with aldosterone receptor inhibitor on ischemic myocardial remodelling and chronic heart failure. Meditsinskiy sovet = Medical Council. 2014;(12):81-85. (In Russ.) https://doi.org/10.21518/2079-701X-2014-12-81-85
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