Nonalcoholic steatohepatitis and intestinal microflora: the question of potential of prebiotic medicines
https://doi.org/10.21518/2079-701X-2013-3-2-46-51
Abstract
More than 30 years ago, Jurgen Ludwig et al. from Mayo Clinic (USA, Minnesota) for the first time at biopsy described typical signs of parenchyma lesions in alcoholic liver disease in patients who did not consume hepatotoxic doses of alcohol but were suffering from obesity and type II diabetes. Histological examination of biopsy specimens revealed not only fatty liver, but also hepatocyte ballooning with concurrent lobular and portal leukocyte infiltration [32]. The resulting morphological picture did not fit into the earlier defined criteria for fatty liver disease; the term "non-alcoholic steatohepatitis" (NASH) was first proposed by the researchers, which subsequently secured its place in the vocabulary of both practitioners and scholars. Further studies in different regions of the world led to separating NASH as a nosological entity in the structure of liver diseases characterized by inflammation and cytolytic syndrome [21, 30, 48, 51].
About the Authors
Yu. A. Kucheryaviy
ГБОУ ВПО «МГМСУ им. А.И. Евдокимова»; ОАО «Лечебный центр», г. Москва
Russian Federation
Russian Federation
E. A. Mayevskaya
ГБОУ ВПО «МГМСУ им. А.И. Евдокимова»
Russian Federation
Russian Federation
M. L. Akhtaeva
ГОУ ВПО «Чеченский государственный университет», г. Грозный
Russian Federation
Russian Federation
E. A. Krasnyakova
ГОУ ВПО «Чеченский государственный университет», г. Грозный
Russian Federation
Russian Federation
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Review
For citations:
Kucheryaviy YA, Mayevskaya EA, Akhtaeva ML, Krasnyakova EA. Nonalcoholic steatohepatitis and intestinal microflora: the question of potential of prebiotic medicines. Meditsinskiy sovet = Medical Council. 2013;(3-2):46-51. (In Russ.) https://doi.org/10.21518/2079-701X-2013-3-2-46-51
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